西安思莫徳科技有限公司生产的纳米孔单分子检测仪器（SIMOLDE NanoF1）是国内首台成熟的单分子专用检测设备，具有集成便携、高性能、可定制、噪音低等核心优势。自主研发了独有的专用集成电路，实现了全信号链的重新设计。
集成便携：检测设备体积小（SIMOLDESMDF1Basic型号产品尺寸约26cm*15cm*9cm，整体占地面积为一本16开书本大小）、抗震和电磁屏蔽性能好，可带到现场，从源头进行样品检测。
信号响应速度快：最高带宽100kHz以上，采样速度最高250kHz。
可定制：根据客户需求，以下参数均可定制：量程范围：±2.5nA至±2.5μA；滤波截止频率：256Hz至100kHz；带宽范围：1kHz至100kHz；施加电压范围：±200mV至±2V。
噪音低：采用标准模块（图b）进行实测，在同样带宽和采样速率下，与elements公司的商业化eONEHS型号仪器对比（图a右），本公司产品（SIMOLDESMDF1Basic型号）的噪音更低
近三年基于纳米孔检测发表的部分高水平论文：
1.Highly shape-and size tunable membrane nanopores made with DNA[J].
Nature Nanotechnology, 2022: 1-6.
2.Multiple rereads of single proteins at single a mino acid resolution using nanopores[J]. Science, 2021, 374, 1509-1513.3.Handling a protein with a nanopore machine[J]. Nature Chemistry, 2021, 13(12): 1160-1162.
4.Directional conformer exchange in dihydrofolate reductase revealed by single-molecule nanopore recordings[J]. Nature Chemistry, 2020, 12(5): 481-488.5.Bottom-up fabrication of a proteasome nanopore that unravels and processes single proteins[J]. Nature chemistry, 2021, 13(12): 1192-1199.
6. De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide[J]. Nature nanotechnology, 2022, 17(1): 67-75.7.Nanopore electro-osmotic trap for the label-free study of single proteins and their
conformations[J]. Nature Nanotechnology, 2021, 16(11): 1244-1250.
8. Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers[J]. Biophysical Journal, 2022, 121(3): 339a.9. On the origins of conductive pulse sensing inside a nanopore[J]. Nature Communications, 2022, 13(1): 1-11.10. Disentangling the recognition complexity of a protein hub using a nanopore[J]. Nature communications, 2022, 13(1): 1-11.11. Combining machine learning and nanopore construction creates an artificial intelligence nanopore for coronavirus detection[J]. Nature communications, 2021, 12(1): 1-8.12. Nanopore-based protein identification[J]. Journal of the American Chemical Society,
2022, 144(6): 2716-2725.
13. A nanopore sensing assay resolves cascade reactions in a multienzyme system[J]. Angewandte Chemie International Edition, 2022, 61(20): e202200866.14. Machine learning assisted simultaneous structural profiling of differently charged proteins in a Mycobacterium smegmatis porin A (MspA) electroosmotic trap[J]. Journal of the American Chemical Society, 2022, 144(2): 757-768.15. Non-binary encoded nucleic acid barcodes directly readable by a nanopore[J]. Angewandte Chemie International Edition, 2022, 61(20): e202116482.16. Programmable nano-reactors for stochastic sensing[J]. Nature communications,
2021, 12(1): 1-13.
17. Aerolysin nanopores decode digital information stored in tailored macromolecular analytes[J]. Science Advances, 2020, 6(50): eabc2661.18. Biological nanopore approach for single‐molecule protein sequencing[J]. Angewandte
Chemie, 2021, 133(27): 14862-14873.
19. Giant single molecule chemistry events observed from a tetrachloroaurate (III) embedded Mycobacterium smegmatis porin A nanopore[J]. Nature communications, 2019, 10(1): 1-11.20. Protein identification by nanopore peptide profiling[J]. Nature communications, 2021, 12(1): 1-9.
